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Mometasone Is A Medium-potency Synthetic Corticosteroid With Antiinflammatory, Antipruritic And Vasoconstrictive Properties. Mometasone Provides A Favorable Ratio Of Topical To Systemic Activity Due To Its Primary Local Effect Along With The Extensive Hepatic Metabolism And The Lack Of Active Metabolites. Though It Is Effective For Treatment Of Asthma, Glucocorticoids Do Not Affect Asthma Symptoms Immediately. Maximum Improvement In Symptoms Following Inhaled Administration Of Mometasone Furoate. Antiinflammatory Actions Of Corticosteroids Are Thought To Involve Phospholipase A2 Inhibitory Proteins, Lipocortins, Which Control The Biosynthesis Of Potent Mediators Of Inflammation Such As Prostaglandins And Leukotrienes. Mometasone Furoate Is Used In The Treatment Of Inflammatory Skin Disorders (Such As Eczema And Psoriasis)(Topical Form) , Allergic Rhinitis (Topical Form) (Such As Hay Fever), Asthma (Inhalation Form) For Patients Unresponsive To Less Potent Corticosteroids And Penile Phimosis. In Terms Of Steroid Strength, It Is More Potent Than Hydrocortisone And Less Potent Than Dexamethasone.
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