It Is Sulfonamide Derivative With Adrenergic Antagonist Activity. Tamsulosin Selectivity Binds To And Blocks The Activity Of Alpha1 Adrenoreceptors In The Human Prostate, Prostatic Capsule, Prostatic Urethra & Bladder Neck. Blockade Of These Adrenoceptors Can Cause Smooth Muscle In The Prostate And Bladder Neck To Relax, Resulting In An Improvement In Urinary Flow Rate. At Least Three Discrete Alpha1-adrenoceptor Subtypes Have Been Identified - Alpha-1a, Alpha-1b And Alpha-1d; Their Distribution Differs Between Human Organs And Tissue. Approximately 70% Of The Alpha1-receptors In Human Prostate Are Of The Alpha-1a Subtype. Tamsulosin Is A Α1 Aadrenergic Receptor Antagonist Used In The Symptomatic Treatment Of Benign Prostatic Hyperplasia (Bph). Tamsulosin Is Used To Improve Urination In Men With Benign Prostatic Hyperplasia (Enlarged Prostate).
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